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In a 12-week study, participants receiving 1 mg daily lost an average of 2.6 kg (approximately 5.7 pounds) compared to 0.8 kg in the placebo group

Meta-analysis of trials in overweight/obese subjects found that once-weekly semaglutide (2.4 mg) significantly reduced fasting total cholesterol, low-density lipoprotein cholesterol (LDL-C), VLDL-cholesterol, and triglycerides (TG), while modestly raising high-density lipoprotein (HDL) cholesterol [56]

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Despite the strong correlation observed between patients experiencing high-fat reductions measured by magnetic resonance imaging proton density fat fraction (MRI-PDFF) and histological biopsy data, the FDA would require biopsy data to make approval decisions

It also reinforces the growing role of dentists in broader healthcare conversations around chronic disease, prevention, and patient wellbeing