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Funding The authors are thankful to the Department of Pharmaceutical Sciences & Technology, Birla Institute of Technology, Mesra, Ranchi, for providing the research funding under the seed money scheme (Grant Number BIT/DRIE/SMS/202425/1877) and the necessary research facilities

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MOTS-C supports mitochondrial energy, insulin sensitivity and endurance

In Brazil, it is estimated that approximately 8.8 million women (about 12.3% of the female population) present symptoms highly suggestive of lipedema, frequently associated with comorbidities like hypertension, anemia, anxiety, and depression.9 Notably, body dissatisfaction and psychological distress have contributed to increased awareness and demand for diagnosis of this condition.3,10 Nevertheless, lipedema continues to be underdiagnosed or misdiagnosed, often confused with conditions such as lymphedema, lipohypertrophy, cellulite (also known as gynoid lipodystrophy), or obesity.10,11 Currently, there is no reliable biomarker or widely accessible diagnostic tool for lipedema