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I., Valenzuela R., VillarCheda B., Guerra M

The measurements were performed either by measuring basal OCR and ECAR or using the Glycolytic Rate Assay according to manufacturers protocol

Excitotoxicity occurs through over-stimulation of glutamate receptors, specifically NMDAR, while in the non-receptor-mediated pathway, high glutamate concentrations reduce cystine uptake by inhibiting the System Xc-, leading to intracellular glutathione depletion and resulting in ROS accumulation, which contributes to increased lipid peroxidation, mitochondrial damage, and ultimately ferroptosis

Anyone with liver disease should be evaluated first

Jankowsky, J

Additionally, flavonoids suppress SREBP-1c-driven lipogenesis and enhance PPAR--mediated -oxidation, thereby alleviating hepatic lipid accumulation (Liu et al., 2021b)