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Of particular relevance to IGF-1 anabolic research are TSC2 (relieving inhibition of mTORC1, driving protein synthesis) and FoxO transcription factors (inhibiting their nuclear translocation, blocking expression of atrogenes like MuRF1 and atrogin-1 that drive muscle protein breakdown)

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[DOI] [PMC free article] [PubMed] [Google Scholar] 173.Paone S., Baxter A.A., Hulett M.D., Poon I.K.H

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