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It is generally accepted that NRF2 is sequestered by KEAP1 in the cytoplasm under normal conditions and is released from KEAP1 before translocating into the nucleus under oxidative stress (Figure 1)

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Although the small bowel is much longer than the large bowel, it has a much narrower diameter, hence the names

PTMs of NRF2 PTMs, such as phosphorylation, acetylation, ubiquitination, methylation, and glycosylation, among others, are largely reversible processes

The pharmacologic profile, mechanism of action, metabolism, clinical uses, and adverse effects of imipramine

Sandstrm BE, Carlsson J, Marklund SL (1989) Selenite-induced variation in glutathione peroxidase activity of three mammalian cell lines: no effect on radiation-induced cell killing or DNA strand breakage