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10.1089/ars.2010.3412 36 FuJ.LiuM.LiuY.WoodburyN

This increased activity naturally leads to the production of more reactive oxygen species, which can cause oxidative stress

Papadakis MA, Grady D, Black D, et al

RSC Adv (2022) 12:387182

The Prevalence and Characteristics of Performance-Enhancing Drug Use Among Bodybuilding Athletes in the South of Iran, Bushehr

Reduced effectiveness despite consistent dosing can also indicate degradation, though this is harder to confirm objectively
