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Disc degeneration and cellular senescence reduce stem cell marker expression (CD90, CD73, TIE2, CD24) and impair spheroid colony-forming unit (CFU-S) capacity in NPPCs, accelerating cellular depletion [69]

To this end, GSH and fumarate, at a concentration found in Fh1-deficient cells 15 , were mixed in a physiological buffer

This section will detail the key mechanisms of ferroptosis, including iron overload, lipid peroxidation and the dysregulation of the antioxidant system (particularly the system XcGPX4 pathway), highlighting their interactions that culminate in cell death and tissue damage (Fig

Lipogenesis Inhibition The Dual-Action Profile In addition to stimulating lipolysis, published preclinical research has documented that AOD-9604 inhibits lipogenesis, the biosynthetic pathway through which excess calories are converted into new triglyceride stores

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Human genetics shape the gut microbiome