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It stimulates the pituitary gland to release growth hormone in a physiologic, pulsatile manner

According to a study published in PubMed Central (National Institutes of Health), intravenous administration of vitamin B12 provides a faster increase in B12 levels compared to oral supplementation, making it a potentially better option for patients with severe deficiency

Tirzepatide suppresses this compensatory ghrelin increase through central nervous system effects, breaking the typical hunger rebound cycle

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