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Thus, we speculate that cisplatin or increased levels of 4-HNE induced by cisplatin stimulates GSTA4 activity in the inner ear of females, but not males, likely because the constitutive expression of inner ear Gsta4 mRNA is significantly higher in females than males and/or females have higher levels of estrogen

Gonadal maturation and reproductive status in C

& Sheen, J

A new target for gold(I) compounds: glutathione-S-transferase inhibition by auranofin

These substances possess multiple hydroxyl groups linked to their chemical structure, making them more effective in neutralizing ROS and reactive nitrogen species and preventing lipid peroxidation
