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80 Clinicians should carefully weigh the potential risks and burdens of particular tests against the potential benefit to patients

Furthermore, increased circulating levels of UA have survival advantages by maintaining blood pressure, improving reaction time and mental performance, and preventing infections or tumors [19]

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Given the evidence linking gut dysbiosis with neurodegenerative disease mechanisms, a variety of strategies are being pursued to modulate the microbiotagutbrain axis for therapeutic benefit (Fig
