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Z.LiY.YuT.LiT.WangJ
This dual inhibition effectively blocks the transdifferentiation and activation of quiescent hepatic stellate cells (HSCs) into collagen-secreting myofibroblasts, markedly decreasing deposition of fibrillar collagen type I (Col I) and -smooth muscle actin (-SMA), while also triggering cell cycle arrest in activated HSCsthereby halting fibrotic expansion

NF1 is a tumor suppressor in neuroblastoma that determines retinoic acid response and disease outcome

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In some cases, liver transplantation may be necessary for individuals with severe liver damage

Inhibition of viral replication by nitric oxide and its reversal by ferrous sulfate and tricarboxylic acid cycle metabolites
