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This dual inhibition effectively blocks the transdifferentiation and activation of quiescent hepatic stellate cells (HSCs) into collagen-secreting myofibroblasts, markedly decreasing deposition of fibrillar collagen type I (Col I) and -smooth muscle actin (-SMA), while also triggering cell cycle arrest in activated HSCsthereby halting fibrotic expansion

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NF1 is a tumor suppressor in neuroblastoma that determines retinoic acid response and disease outcome

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In some cases, liver transplantation may be necessary for individuals with severe liver damage

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Inhibition of viral replication by nitric oxide and its reversal by ferrous sulfate and tricarboxylic acid cycle metabolites

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