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340 Furthermore, the increased production of inflammatory mediators like TNF- and the activation of stress kinases such as JNK, PKR, and IKK could promote the inhibitory serine phosphorylation of IRS-1, downregulate insulin signaling in the brain, and induce AD neurological dysfunction

Studies on CHAC 1 and CHAC 2 have shown that the two isoenzymes both promote the intracellular degradation of GSH, but they appear to act in different contexts

doi:10.1073/pnas.0702854104

[DOI] [PubMed] [Google Scholar] Tucci P

K.PhamC.FoppenE.DenisR
And tumors were weighed every week
