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These ROS are capable of causing uncontrolled oxidation of various cellular components that can lead to oxidative damage of the cell (Asada, 2001

This is the primary pathway for detoxifying acetaminophen (paracetamol), heavy metals, and numerous environmental toxins [2][6]

Moreover, it may play a role in muscle cells, neuronal cells, and the endoplasmic reticulum (354)

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The activity of these enzymes is enhanced by a variety of chemicals, including caffeine[40, 41] and anticonvulsant drugs[42], and it is well known that co-ingestion of these drugs with APAP can greatly enhance the toxicity of APAP