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El SPJ muestra una herencia autosmica dominante, el defecto se sita en el cromosoma 19 q13.3, pero hasta el 40% de los pacientes con esta enfermedad reportan antecedentes patolgicos familiares negativos1
Furthermore, Clokey and Jacobson reported over two decades ago that exogenous fluorescent probes are taken up by endocytosis and accumulate within the autofluorescent lipofuscin granules, which are the secondary lysosomes and active recipients of endocytosed fluorescent probes [20]

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The spots are lightened and the skin's texture is also improved