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In June, the European Medicines Agencys PRAC identified NAION as a very rare adverse event linked to semaglutide and recommended updating product labels with vision warnings

GLP-1 may act on bone by promoting bone formation, inhibiting bone resorption, and affecting the coordination of the two processes

Prednisone is a potent anti-inflammatory medication belonging to the corticosteroid class

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GLP-1 medications, such as semaglutide (brand names Ozempic, Wegovy) and liraglutide (Saxenda, Victoza), mimic the effects of the naturally occurring GLP-1 hormone in the body

SGLT-2is promote a metabolic transition toward ketogenesis by enhancing hepatic lipid oxidation and increasing circulating ketone bodies, which serve as efficient energy substrates for the kidneys and heart [30]