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JAMA 310, 15911600

We found that expression of these PM signature genes correlated extremely well with the 366 genes identified in our study, and with the CMS4 signature genes from the original random forest classifier, both in our CRC-PM cohort and in the original large composite CMS cohort (Supplementary Fig

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Some experimental results suggest significant increases in circulating IGF-1, which is thought to act as a downstream mediator of growth hormone activity