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[] Hassan et al [] found that the combination of GEM and doxorubicin with quercetin down-regulated the expression of hypoxia-inducible factor and increased the expression of the apoptosis-regulating factor p53, thus promoting apoptosis and reducing chemotherapy resistance

[DOI] [PubMed] [Google Scholar] 13.Rossi R., Chiurlia E., Nuzzo A., Cioni E., Origliani G., Modena M.G

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Abstract Ferroptosis is a non-apoptotic mode of programmed cell death characterized by iron dependence and lipid peroxidation

M2-polarized TAMs collaborate with angiogenic factors, including epidermal growth factor (EGF) and placental-derived growth factor, within the TME

At the same time, molecules with multiple hydroxyl groups, especially in the B-ring, significantly increased the amount of hydroxyl radicals in the Fenton reaction [36]