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These include: Lifestyle interventions (dietary advice, physical activity programmes) Licensed pharmacotherapy such as orlistat, or GLP-1 receptor agonists including semaglutide 2.4 mg (Wegovy, NICE TA875) or tirzepatide (Zepbound) where clinically indicated and available Referral to tier 3 or tier 4 weight management services , including bariatric surgery assessment where appropriate Information on NHS weight management services and eligibility for licensed treatments is available via the NHS website and NICE guidance

Weather: The ascent can be more complicated on rainy or foggy days, so it is recommended to check the weather conditions before starting

Reconstitution Best Practices: When reconstituting AOD-9604 , allow both the peptide vial and bacteriostatic water to reach room temperature to minimize temperature shock

DOI: 10.1016/j.arcped.2015.12.005 47

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Post-workout administration during the fed state wastes the fasted-window advantage entirely