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First, we used CMS4-derived organoids (from a patient with PM) in which the catalytic subunit of glutamate-cysteine ligase (GCLC) was deleted using CRISPR-CAS9 technology

At the same time, they exhibit an anti-apoptotic signaling, as an attempt by the system to recover from the injury

Implications of reactive oxygen species on cancer formation and its treatment

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In silico genome-wide identification and characterization of the glutathione S-transferase gene family in Vigna radiata

Free Radic Biol Med 65:789799 Ibez L, Ferrndiz ML, Brines R, Guede D, Prez-Crceles MD, Alcaraz MJ (2014) Effects of Nrf2 deficiency on bone microarchitecture in an experimental model of osteoporosis