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In summary, androgens and AR can promote mitochondrial fusion and prevent fragmentation by elevating the fusion-related proteins and inhibiting the fission-related proteins, ultimately affecting the quality and function of mitochondria in males

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278,279 Lifestyle interventions, particularly aerobic exercise, have also demonstrated benefits in enhancing mitochondrial biogenesis and function, offering a non-pharmacological approach to managing DPN (Fig

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and Volek, J.S