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An additional clinically significant group of enzymes that requires tetrahydrobiopterin as cofactor are the nitric oxide synthase (NOS) family of enzymes
Methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C polymorphisms and age of onset in schizophrenia: a combined analysis of independent samples

CrossRef Thyroid diseases and risk of non-thyroidal pathology R I Glushakov, E V Kozyrko, I V Sobolev, S A Ermolova, O V Vlaseva, A A Kuzin, N I Tapilskaya Kazan medical journal.2017

The reason is attributed to the extremely low or no reactivity of cyanobacterial CrtR towards a substrate with a 4-keto--end group

FUS-induced BBB opening was further examined in vivo using a transcranial FUS exposure setup (Figs
