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Description
Although the precise mechanism by which benzene induces leukemia is not known, the prevailing hypothesis is as follows (Figure 1).45 Benzene is metabolized in the liver primarily by cytochrome P4502E1 (CYP2E1), first to benzene oxide and then to phenol, hydroquinone and other polyphenolic metabolites
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Methods 247 , 175186 (2001)

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