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Clin Med Insights Endocrinol Diabetes 13:57 Ajiboye BO, Ojo OA, Fatoba B, Afolabi OB, Olayide I, Okesola MA, Oyinloye BE (2019) In vitro antioxidant and enzyme inhibitory properties of the n-butanol fraction of Senna podocarpa (Guill and Perr.) leaf

328,331,332 The Chinese medicine monomer ferulic acid improves cognitive dysfunction and reduces hippocampal neuron damage by activating SIRT1/Nrf2-mediated ferroptosis

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however, the presence of higher bands in pellet fractions, which correspond to uncleaved and signal peptidase-cleaved forms, determined previously 9 indicate the 16Ala mutant form was cleaved inefficiently by PMV, which may explain why export was slightly less than the control (Fig

Moreover, cardiomyocyte-specific knockdown of HADHA exacerbated cardiac dysfunction in mice, whereas treatment with Fer-1, an inhibitor of ferroptosis, effectively rescued cardiac function, supporting the conclusion that HADHA deficiency promotes ferroptosis predominantly through reactive oxygen species accumulation and glutathione depletion

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