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Wang H, Yang J, Zhao BX, Ha L, Liu YM, Huang C, Yu MY, Hui X, He R, Han L

Effects in other conditions Five studies focused on the effects of IF on special populations, including individuals in special physiological states, such as during pregnancy or before or after an operation, and individuals with conditions such as polycystic ovary syndrome (PCOS), multiple sclerosis (MS), or chronic myelogenous leukemia (CML) (Table 3)

R.et al (2014)
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doi: 10.1016/j.exer.2015.09.007

It seems, therefore, that the route of vitamin B12 administration is an important factor in determining the probability of developing a hypersensitivity reaction to cobalamin
