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Part A is an assessment of single ascending doses from 350 mg SC QW, Part B is an assessment of four multiple ascending doses from 340 mg SC QW, and Part C is an open label assessment of four multiple ascending doses from 1040 mg SC QW

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Nat Commun 4: 2753 Love MI, Huber W, Anders S (2014) Moderated estimation of fold change and dispersion for RNAseq data with DESeq2

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