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J Agric Food Chem 54:69456950 Ullah H, Khan H (2020) Epigenetic drug development for autoimmune and inflammatory diseases

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More specifically, the present invention relates to a process for preparing L-carnitine or acetyl L-carnitine hydrochloride, comprising sequentially synthesizing racemic 4-chloro-3-hydroxybutyronitrile of Formula 2 and racemic 4-chloro-3-hydroxy butyric acid alkyl ester of Formula 3 under specific reaction conditions, using racemic epichlorohydrin of Formula 1 as a starting material, preparing (R)-4-chloro-3-hydroxy butyric acid alkyl ester of Formula 4 from stereoselective hydrolysis of the racemic 4-chloro- 3 -hydroxy butyric acid alkyl ester in an aqueous solution using an enzyme, and preparing L-carnitine of Formula 6 or acetyl L-carnitine hydrochloride of Formula 7 from the (R)-4-chloro-3-hydroxy butyric acid alkyl ester

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Ketone metabolites (NLRP3 variant) : -hydroxybutyrate, a metabolite formed in ketosis, blocks the NLRP3 inflammasome.[ref] The body produces -hydroxybutyrate on a ketogenic diet (low carb, high fat)

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Apr2022;15(4):433-442

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Always inform your prescribing doctor about supplements, particularly if you are taking metformin, anticoagulants, thyroid medication, or any medication for a chronic condition

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