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Systemic administration (injectable or oral), which is less common than topical use and not part of approved or standard applications, would theoretically carry different safety considerations requiring appropriate clinical evaluation, though limited research on parenteral administration in animals has suggested acceptable safety profiles at moderate doses

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However, CORT can also activate the JAK2/STAT3 signaling pathway, suggesting that there is another mechanism by which CORT inhibits SOCS1 that warrants further exploration