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Useful for this discussion is a recent meta-analysis of MRS studies, which found that physical activity, rather than sedentary lifestyle, is related to higher brain lactate [81]

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Allosteric regulation of ARs transcriptional activity The mechanistic insights reported above are consistent with allosteric regulation of transcription factor action, in which the type of DNA motif to which the factor binds and its protein and ligand interactions influence its conformational plasticity and the availability of tunable multimerization and protein interaction surfaces that control context-dependent and gene-specific transcriptional activity [78, 80]