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The additive effects observed when combining NNMT inhibition with exercise indicate that the compound influences molecular pathways distinct from those activated by physical training alone

Park, J

Aging 2 , 254263 (2022)

neurological involvement requires more frequent maintenance dosing

In vitro studies confirm minimal cytotoxicity with no impact on cell viability up to 100 M concentrations across multiple cell types, though higher concentrations may produce non-specific effects that could confound experimental results