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Pharmacological targeting of CHAC1-mediated processes therefore represents a rational therapeutic strategy, potentially disrupting the cycle of GSH depletion, ER stress amplification and iron-dependent peroxidation that drives neuronal loss

Although the mammalian GGTs were the first to be described in detail, heavy glycosylation and membrane-bound localization made it difficult to determine their structure

A 2025 intravenous safety study involving two healthy adults found infusions up to 20 mg well tolerated, with no adverse events or clinically meaningful changes in vital signs or laboratory biomarkers

injectable glucagon-like peptide-1 receptor agonists (GLP-1 RAs) in subjects with type 2 diabetes (T2D) inadequately controlled on basal insulin were assessed using network meta-analysis (NMA)

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10.1186/1472-6793-5-5 BMC Physiol