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Scientists have found good ways to block CD38: Apigenin, a natural flavonoid, stops CD38 from working and increases NAD+ inside cells Thiazoloquin(az)olin(on)e (78c) blocks CD38 so well it doubles NAD+ in normal cells but doesn't affect cells without CD38 NAMPT activation to improve NAD+ recycling NAMPT controls the key step in NAD+ recycling by turning nicotinamide into NMN

10.1038/s41419-021-04046-3 Cell Death Dis

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(128) found that Clostridium is more abundant in the gut of arthritis-susceptible mice

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