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Creatine acts like a cellular battery charger

In a mouse model of melanoma lung metastasis, PTX-CPTs significantly inhibited the numbers of tumor nodules and percent metastasis area covered by melanoma cells in the lung, and reduced respiratory complications and side effects of chemotherapeutic agents

Therefore, targeting CSCs is a key area of cancer research during the past 30 years, with the potential to more effectively prevent relapses for lasting cancer treatments (Makena et al., 2020)

Accessed 3 Mar 2025

Nat Cell Biol 16:11801191 Yang WS, SriRamaratnam R, Welsch ME, Shimada K, Skouta R, Viswanathan VS, Cheah JH, Clemons PA, Shamji AF, Clish CB et al (2014) Regulation of ferroptotic cancer cell death by GPX4

This role also makes ornithine supplementation important for those with any form of liver deficiency