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The treatment of MAFLD primarily involves weight loss of 710% (0.51 kg per week) through reduced caloric intake (by 500600 kcal/ day) and 150 min of aerobic exercise per week [58]

However, it's crucial to understand that Semaglutide is most effective when paired with lifestyle changes, including diet and exercise

We offer the GLP-1 Daily Support supplement to assist with this process

Rheumatology providers should also be aware of potential challenges: GI side effects that may complicate the use of methotrexate or NSAIDs

This careful, structured increase is a fundamental part of the treatment process

All references FDA: Concerns with unapproved GLP-1 drugs used for weight loss NEJM (2023): Retatrutide Phase 2 trial in obesity Eli Lilly: Phase 2 retatrutide results published in NEJM Eli Lilly (Dec 2025): Phase 3 TRIUMPH-4 topline results announcement ClinicalTrials.gov: NCT05882045 (TRIUMPH-3) Drugs.com: Retatrutide status & timeline Lilly Trials: TRIUMPH-3 summary page