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3,4 Moreover, experiments involving drug-resistant cell lines have also demonstrated increased GST expression

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Dysfunctions of protein quality control systems such as the autophagy-lysosomal system are well demonstrated in SOD1 G93A mice and ALS patients 41, 42

Solubility enhancers The production of recombinant proteins in bacterial hosts can lead to the formation of protein aggregates with unfolded or partially folded structures (Demain and Vaishnav, 2009, Lange and Rudolph, 2008), termed inclusion bodies (IBs) (Garca-Fruits et al., 2012)

ChemMedChem (2018) 13(12):116571