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In a randomized placebo-controlled trial in older men, supplementation with folate, vitamin B 6 and vitamin B 12 daily for 2 years decreased homocysteine levels and reduced the rate of increase in circulating levels of amyloid-140 (Flicker et al., 12 (Durga et al., 12 /folate was observed indicating that other reasons for hyperhomocysteinemia may operate (Farina et al., Suboptimal Activity of the Reverse Transsulfuration Pathway The reverse transsulfuration pathway leads to the production of cysteine, the availability of which is the rate-limiting step for glutathione (GSH) biosynthesis

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