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Nauck et al., 2020): Compounds based on the lizard-derived exendin-4 peptide and compounds based on the human GLP-1 peptide

Patients with longstanding diabetes (over 10 years) or poor prior glycemic control should undergo comprehensive dilated eye examination before starting GLP-1 medications to establish baseline retinal status

But there are several side effects like digestive distress, weight regain, and other issues that may make taking these medications difficult or impossible
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c , d , representative 2 F o F c electron density contoured at 1.0 across the orthosteric peptide-binding pocket of GLP-1R

Puddu et al
