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Introduction: Introduction: AOD-9604 is a synthetic peptide fragment of human growth hormone (hGH 177191) engineered to replicate hGHs fat-metabolism effects without altering IGF-1 or glucose levels. In preclinical research, it promoted lipolysis (fat breakdown) and reduced lipogenesis (fat storage) through receptor-independent mechanisms. AOD-9604 Fast Facts Class: Synthetic hGH fragment analog (Tyr-hGH 177191) Intended purpose: Stimulate fat metabolism while avoiding hGHs growth or glucose effects Mechanism: Increases fat oxidation, enhances lipolysis, suppresses lipogenesis Distinct from hGH: Does not activate the growth hormone receptor or raise IGF-1 Development stage: Completed Phase II trials

2.6 Meta-analysis Meta-analysis was performed using the R statistical program, R version 4.4.2 (The R Foundation for Statistical Computing, Wirtschaftsuniversitt Wien, Vienna, Austria) (Sterne et al., 2016