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It can be further oxidized to N-methyl-2-pyridone-5-carboxamide (2PY) and N-methyl-4-pyridone-3-carboxamide (4PY) in vivo and is easily excreted in urine in the forms of MNA, 2PY, and 4PY (in humans, the major metabolite of MNA is 2PY, and in rodents, the major metabolite of MNA is 4PY) [6567]

Journal of the American Geriatrics Society 2002;50(4):62430

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Minoxidil comes with scalp irritation (usually traced back to the propylene glycol in the liquid) and a shedding phase in the first few weeks