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MEDI7247 has shown remarkable antitumor activity in hematological malignancies such as AML, MM, diffuse large B cell lymphoma (DLBCL), acute lymphoblastic leukemia (ALL), Burkitt lymphoma, as well as solid tumors including colorectal cancer, small cell lung cancer, and head and neck squamous cell carcinoma (Pore et al., 2018

Multipotent Lgr-5 expressing stem cells reside near the base of the intestinal crypt and give rise to daughter cells that migrate up the crypt

However, research on TGME49_216510 ( T

Recommended dosing is the same for monotherapy and adjunctive therapy

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