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These impressive findings also underscore the importance of employing multiple temporal scalescrafting both longer- and shorter-term chronologies to monitor the nuances in how indigenous societies transformed and perpetuated themselves (Mitchell and Scheiber 2010:17

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A randomised, double-blind, placebo-controlled trial in dyslipidaemic patients (the ROSE trial, NCT04753606) showed that obicetrapib at oral doses of 5 mg and 10 mg, compared with placebo, as an adjunct to intensive statin therapy (40 mg or 80 mg of atorvastatin or 20 mg or 40 mg of rosuvastatin) resulted in reductions in Lp(a) of 33.8% and 56.5%, respectively [178] (Table VIII)

In mice fed with HFD, the citrate synthase activity, ATP production, mitochondrial respiration and mitochondrial DNA (mtDNA) content in skeletal muscle are significantly decreased [73]