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For example, intermittent hemodialysis may be impeded for several weeks owing to pigment distribution across the dialysate membrane with subsequent triggering of a colorimetric alarm designed to detect blood leaks.4 Continuous renal replacement therapy, however, is unaffected

Novel approaches utilising red-shifted dyes to reduce autofluorescence and to allow multiplexing of samples are also emerging

These animals are more prone to develop ethanol-induced liver injury, which may be at least partly due to these changes

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Furthermore, another study in zebrafish also found that exposure to concentrated copper (111000 g/L) led to faster heart rates at 28 h postfertilization (hpf) zebrafish embryos, suggesting a stress response in fish embryos [35]