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Studies specifically evaluating tirzepatide in people with various degrees of renal impairment found similar drug exposure across all groups, including those with severe kidney impairment

The Lancet Diabetes & Endocrinology , 12(2), 89-101

Rodrguez-Colman MJ, Schewe M, Meerlo M et al (2017) Interplay between metabolic identities in the intestinal crypt supports stem cell function

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To date, the M1 profile appears to be generally protective against bacterial and viral infections

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