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Istanbul, Turkey) was administered intraperitoneally (i.p.) at a dose of 45 mg/kg20 to the respective animal groups on day-7 of the experimental protocol

The data, together with the data from the same study measuring pyruvate levels described above, indicate that fasting increased the fumarate/pyruvate, and so also likely increased the malate/pyruvate, indicative of the [NADPH]/[NADP + ], in the spinal cord and several brain regions, including the hippocampus, brainstem, olfactory bulb, and potentially to a smaller extent in the cortex, while potentially decreasing in the hypothalamus (Shao et al., 2023)

For instance, conditions like pernicious anaemia affect around 1 in 1,000 people in the UK and require lifelong treatment

Auktionen avser 2st

doi: 10.1038/s41467-019-08352-5, 105 RouaultT

published 8 March 2016 1