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However, the Thr111Ile variant was shown in in vitro assays to be indiscernible from wild-type EL [34]

Nov 2013;112(7):885-897

Essays Biochem (2010) 47:6984

Conversely, adipose sphingolipid profiling upon cold challenge or 3-adrenergic agonism reveals a reduction in intermediates involved in sphingolipid production, such as ceramide, dihydroceramide, and sphinganine, in WAT, indicating that regulation of sphingolipids may contribute to the thermogenic properties of WAT

A fourteen-day continuous intraventricular infusion of MT-II in normal C57BL/6J mice did not induce any significant changes in sociability or social novelty scores compared to vehicle-treated controls