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Another way of considering the chemical basis of these complementary approaches is to note that in procedure A, we leverage the fact that in solution, the deprotonated terminal perthiolate and perthiolate-like sulfur atoms in polysulfides have nucleophilic chemical properties and thus react with IAM/IAM-TPP

Most of them originate from the mitochondrial respiratory chain

For example, in the liver, Reznick et al

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While most published animal studies use once-daily dosing, some research protocols investigate twice-daily administration, particularly for acute injury models or when mimicking the continuous exposure that might occur with oral dosing