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In parallel, excessive Cu + generated in GSH-rich reductive environments can bind lipoylated mitochondrial TCA-cycle proteins such as DLAT, inducing aberrant protein aggregation and triggering cuproptosis across multiple cancer types 187,189,192-194

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Together, these modalities allow physicians to tailor treatment according to a patients conditionsometimes starting with peptides or exosomes for maintenance and reserving cells for more advanced conditions

10.1016/j.jtbi.2003.08.001 34 ReedM

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