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Overall, the defect in cortisol regulation in SAD may be missed if the CAR isnt assessed along with the diurnal rhythm

NO may be produced by type 1 NOS (also known as neuronal NOS), which is induced by oxidative stress in alveolar epithelial cells of COPD patients [112]

[DOI] [PMC free article] [PubMed] [Google Scholar] 44.Holstein-Rnsbo S, Gan Y, Giannetto MJ, Rasmussen MK, Sigurdsson B, Beinlich FRM, Rose L, Untiet V, Hablitz LM, Kelley DH, Nedergaard M

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( 5.2 Oxidative stress Oxidative stress represents a pivotal mechanism in COPD pathogenesis, defined as an imbalance between the bodys oxidative and antioxidant systemseither due to excessive production of reactive oxygen species (ROS) or impaired antioxidant capacity