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Evidence in support of chromosomal sex influencing plasma based metabolome vs APOE genotype influencing brain metabolome profile in humanized APOE male and female mice

The activity of fat burners in the human body is largely based on blocking the activity of lipase - an enzyme responsible for digesting fats from food

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For one thing, there is no evidence that the negative effect reported can be replicated outside of the mouse model used

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However, larger randomized controlled trials are needed to further assess these results