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doi: 10.1038/nature09663 142 QuXZouZSunQLuby-PhelpsKChengPHoganRNet al

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Proteins such as apolipoprotein C3 (APOC3), APOA1, stathmin 1 (STMN1), HSPB1, p21 (RAC1) activated kinase 2 (PAK2), TGF-, apoptosis-inducing enzyme caspase-3 (CASP3), COL1A2, collagen type IV alpha 1 chain (COL4A1), laminin subunit beta 4 (LAMB4), and THBS1 were found to be significantly enriched in these pathways [52]

These findings suggest TMAO is more indicative of microbial disruption than a driver of IBD pathogenesis, highlighting limitations in translating experimental models to clinical disease (129)

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Prevalence of varicocele among primary and secondary infertile men: association with occupation, smoking and drinking alcohol