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It is more and more taken into consideration that gluten does not seem to be the only cause of discomfort in wheat-sensitive patients [29]

10.1016/B978-0-444-62619-6.00010-0 Handbook of Clinical Neurology 23 ChowB
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Heparin is also thought to inhibit the binding of IGFBP-3 to extracellular matrix heparan sulfate proteoglycans, thereby reducing the affinity of IGFBPs for IGF-I administration and resulting in the release of IGFBP-3 from the cell surface (Losa et al., 1999)

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